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Proceedings Paper

Label-free single-molecule all-optical sensor
Author(s): Andrea M. Armani; Scott E. Fraser; Richard C. Flagan
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Paper Abstract

Recently, quality factors greater than 100 million were demonstrated using planar arrays of silica microtoroid resonators. These high Q factors allow the toroidal resonators to perform very sensitive detection experiments. By functionalizing the silica surface of the toroid with biotin, the toroidal resonators become both specific and sensitive detectors for Streptavidin. One application of this sensor is performing detection in lysates. To mimic this type of environment, additional solutions of Streptavidin were prepared which also contained high concentrations (nM and μM) of tryptophan.

Paper Details

Date Published: 7 February 2008
PDF: 9 pages
Proc. SPIE 6852, Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VIII, 68520A (7 February 2008); doi: 10.1117/12.761007
Show Author Affiliations
Andrea M. Armani, California Institute of Technology (United States)
Scott E. Fraser, California Institute of Technology (United States)
Richard C. Flagan, California Institute of Technology (United States)


Published in SPIE Proceedings Vol. 6852:
Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications VIII
Israel Gannot, Editor(s)

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