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Proceedings Paper

Optical stimulation of the cavernous nerves in the rat prostate
Author(s): Nathaniel M. Fried; Gwen A. Lagoda; Nicholas J Scott; Li-Ming Su; Arthur L. Burnett
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Paper Abstract

Laser nerve stimulation has recently been studied as an alternative to electrical stimulation in neuroscience. Advantages include non-contact stimulation, improved spatial selectivity, and elimination of electrical stimulation artifacts. This study explores laser stimulation of the rat cavernous nerves, as a potential alternative to electrical nerve mapping during nerve-sparing radical prostatectomy. The cavernous nerves were surgically exposed in a total of 10 male rats. A Thulium fiber laser stimulated the nerves, with a wavelength of 1870 nm, pulse energy of 7.5 mJ, radiant exposure of 1 J/cm2, pulse duration of 2.5 ms, pulse rate of 10 Hz, and 1-mm laser spot diameter, for a stimulation time of 60 s. A significant increase in the intracavernosal pressure was detected upon laser stimulation, with pressure returning to baseline levels after stimulation. This study demonstrates the feasibility of non-contact laser stimulation of the cavernous nerves using near-infrared laser radiation.

Paper Details

Date Published: 8 February 2008
PDF: 6 pages
Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 684213 (8 February 2008); doi: 10.1117/12.760950
Show Author Affiliations
Nathaniel M. Fried, Univ. of North Carolina at Charlotte (United States)
Gwen A. Lagoda, Johns Hopkins School of Medicine (United States)
Nicholas J Scott, Univ. of North Carolina at Charlotte (United States)
Li-Ming Su, Johns Hopkins School of Medicine (United States)
Arthur L. Burnett, Johns Hopkins School of Medicine (United States)


Published in SPIE Proceedings Vol. 6842:
Photonic Therapeutics and Diagnostics IV
Kenton W. Gregory; Guillermo J. Tearney; Reza S. Malek; Nikiforos Kollias; Bernard Choi; Haishan Zeng; Brian Jet-Fei Wong; Justus F. R. Ilgner; Henry Hirschberg; Steen J. Madsen, Editor(s)

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