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Proceedings Paper

Combination of photodynamic therapy and immunotherapy - evolving role in dermatology
Author(s): Xiu-Li Wang; Hong-Wei Wang; Zheng Huang
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Paper Abstract

Photodynamic therapy (PDT) is a promising treatment modality. It offers alternative options in the treatment of cancer and vascular diseases. In cancer treatment, PDT has been used primarily for localized superficial or endoluminal malignant and premalignant conditions. More recently, its application has also been expanded to solid tumors. However, its antitumor efficacy remains debatable and its acceptance still variable. Pre-clinical studies demonstrate that, in addition to the primary local cytotoxicity, PDT might induce secondary host immune responses, which may further enhance PDT's therapeutic effects on primary tumor as well as metastasis. Therefore, PDT-induced local and systemic antitumor immune response might play an important role in successful control of malignant diseases. Furthermore, PDT's antitumor efficacy might also be enhanced through an effective immunoadjuvant or immunomodulator. Our recent clinical data also indicate that improved clinical outcomes can be obtained by a combination of PDT and immunomodulation therapy for the treatment of pre-malignant skin diseases. For instance, the combination of topical ALA-PDT and Imiquimod is effective for the treatment of genital bowenoid papulosis. This presentation will also report our preliminary data in developing combination approaches of PDT and immunotherapy for actinic keratosis (AK), basal cell carcinomas (BCCs) and Bowen's disease.

Paper Details

Date Published: 18 February 2008
PDF: 7 pages
Proc. SPIE 6857, Biophotonics and Immune Responses III, 685704 (18 February 2008); doi: 10.1117/12.760769
Show Author Affiliations
Xiu-Li Wang, Shanghai Skin Diseases and STD Hospital (China)
Hong-Wei Wang, Shanghai Skin Diseases and STD Hospital (China)
Zheng Huang, Health Sciences Ctr., Univ. of Colorado, Denver (United States)


Published in SPIE Proceedings Vol. 6857:
Biophotonics and Immune Responses III
Wei R. Chen, Editor(s)

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