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Proceedings Paper

Using NIR spatial illumination for detection and mapping chromophore changes during cerebral edema
Author(s): David Abookasis; Marlon S. Mathews; Christopher M. Owen; Devin K. Binder; Mark E. Linskey; Ron D. Frostig; Bruce J. Tromberg
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Paper Abstract

We used spatially modulated near-infrared (NIR) light to detect and map chromophore changes during cerebral edema in the rat neocortex. Cerebral edema was induced by intraperitoneal injections of free water (35% of body weight). Intracranial pressure (ICP) was measured with an optical fiber based Fabry-Perot interferometer sensor inserted into the parenchyma of the right frontal lobe during water administration. Increase in ICP from a baseline value of 10 cm-water to 145 cm-water was observed. Following induction of cerebral edema, there was a 26±1.7% increase in tissue concentration of deoxyhemoglobin and a 47±4.7%, 17±3% and 37±3.7% decrease in oxyhemoglobin, total hemoglobin concentration and cerebral tissue oxygen saturation levels, respectively. To the best of our knowledge, this is the first report describing the use of NIR spatial modulation of light for detecting and mapping changes in tissue concentrations of physiologic chromophores over time in response to cerebral edema.

Paper Details

Date Published: 26 February 2008
PDF: 6 pages
Proc. SPIE 6842, Photonic Therapeutics and Diagnostics IV, 68422U (26 February 2008); doi: 10.1117/12.760516
Show Author Affiliations
David Abookasis, Beckman Laser Institute and Medical Clinic (United States)
Marlon S. Mathews, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)
Christopher M. Owen, Univ. of California, Irvine (United States)
Devin K. Binder, Univ. of California, Irvine (United States)
Mark E. Linskey, Univ. of California, Irvine (United States)
Ron D. Frostig, Univ. of California, Irvine (United States)
Bruce J. Tromberg, Beckman Laser Institute and Medical Clinic (United States)
Univ. of California, Irvine (United States)


Published in SPIE Proceedings Vol. 6842:
Photonic Therapeutics and Diagnostics IV
Kenton W. Gregory; Guillermo J. Tearney; Reza S. Malek; Nikiforos Kollias; Bernard Choi; Haishan Zeng; Brian Jet-Fei Wong; Justus F. R. Ilgner; Henry Hirschberg; Steen J. Madsen, Editor(s)

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