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Proceedings Paper

Progress on noninvasive and minimally invasive methods on transcutaneous blood glucose sensing
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Paper Abstract

Noninvasive and minimally invasive blood glucose sensing is one of most interesting research fields. For the noninvasive measurement using near-infrared spectroscopy, the optical signal was impaired by the uncertain physiological noise and systematical drift. A floating reference method by differentially processing two signals from reference point and measuring point was used to deal with these uncertain noises. For the minimally invasive measurement, interstitial fluid extracted by ultrasound and vacuum is investigated. Low-frequency ultrasound was applied to enhance the skin permeability to interstitial fluid by disrupting the stratum corneum lipid bilayers. In this paper, a kind of protein absorbing the glucose specifically called D-galactose/D-glucose Binding Protein (GGBP) was introduced to construct a novel surface plasmon resonance (SPR) measuring system. By immobilizing GGBP onto the surface of the SPR sensor, a new detecting system for glucose testing in mixed solution was developed. The experimental result indicated that, the SPR system succeeded in distinguishing glucose resolution of 0. 1 mg/L, and had linear relationship between 0.5 mg/L and 5 mg/L.

Paper Details

Date Published: 8 January 2008
PDF: 10 pages
Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 682616 (8 January 2008); doi: 10.1117/12.760307
Show Author Affiliations
Kexin Xu, Tianjin Univ. (China)
Rong Liu, Tianjin Univ. (China)
Jin Liu, Tianjin Univ. (China)
Wenliang Chen, Tianjin Univ. (China)
Dachao Li, Tianjin Univ. (China)
Zhenhui Du, Tianjin Univ. (China)

Published in SPIE Proceedings Vol. 6826:
Optics in Health Care and Biomedical Optics III
Xingde Li; Qingming Luo; Ying Gu M.D., Editor(s)

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