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Proceedings Paper

Photoacoustic and thermoacoustic imaging application in cancer early detection and treatment monitoring
Author(s): Da Xing; Liangzhong Xiang
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Paper Abstract

Laser-based photoacoustic imaging and microwave-based thermoacoustic imaging, combining the advantages of both the high image contrast that results from electromagnetic absorption and the high resolution of ultrasound imaging, could be the next successful generation imaging techniques in biomedical application. It can provide an effective approach of tissue structure and functional images to study the architectures, physiological and pathological properties and metabolisms of biological tissues. This paper is focused on photoacoustic and thermoacoustic imaging application in cancer early detection and treatment monitoring. A unique photoacoustic imaging system was used to detect tumors neovascularization associated with angiogenesis in a rat animal model. We also developed the imaging system to monitor the vascular damage during photodynamic therapy treatment. This method could be potentially used to guide PDT and other phototherapies using vascular changes during treatment to optimize treatment protocols, by choosing appropriate types and doses of photosensitizers, and doses of light. Potentially development of photoacoustic imaging and thermoacoustic imaging to employing in functional and molecular imaging also has been discussed. Especially, these imaging modalities can be further developed by using the contrast agents which modified with tumor-targeting antibodies to realize cancer early detection and cancer target treatment monitoring.

Paper Details

Date Published: 8 January 2008
PDF: 8 pages
Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68260B (8 January 2008); doi: 10.1117/12.760230
Show Author Affiliations
Da Xing, South China Normal Univ. (China)
Liangzhong Xiang, South China Normal Univ. (China)

Published in SPIE Proceedings Vol. 6826:
Optics in Health Care and Biomedical Optics III
Xingde Li; Qingming Luo; Ying Gu M.D., Editor(s)

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