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Proceedings Paper

In vivo Raman spectroscopy for breast cancer: diagnosis in animal model
Author(s): R. Bitar; M. A. Martins; D. Ribeiro; C. Carvalho; E. A. P. Santos; L. N. Z. Ramalho; F. Ramalho; H. Martinho; A. A. Martin
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Paper Abstract

Raman spectroscopy has been well established as a powerful method for studying biological tissues and diagnosing diseases. In this study we have developed a breast cancer animal model and collected in vivo Raman spectra of mammary glands of 27 Sprague-Dawley female rats treated with DMBA and 5 non-treated used as control group. A dispersive Raman spectrometer with a @785 nm laser excitation coupled a fiber optic probe and a CCD detector was used to obtain the spectra. The obtained in vivo transcutaneous Raman spectra have shown important differences between normal and abnormal tissues when acquired from one side to the other side of the lesion.

Paper Details

Date Published: 8 February 2008
PDF: 7 pages
Proc. SPIE 6853, Biomedical Optical Spectroscopy, 68530O (8 February 2008); doi: 10.1117/12.760089
Show Author Affiliations
R. Bitar, UNIVAP (Brazil)
M. A. Martins, UNIVAP (Brazil)
D. Ribeiro, UNIVAP (Brazil)
C. Carvalho, UNIVAP (Brazil)
E. A. P. Santos, UNIVAP (Brazil)
L. N. Z. Ramalho, USP (Brazil)
F. Ramalho, USP (Brazil)
H. Martinho, UNIVAP (Brazil)
A. A. Martin, UNIVAP (Brazil)


Published in SPIE Proceedings Vol. 6853:
Biomedical Optical Spectroscopy
Anita Mahadevan-Jansen; Wolfgang Petrich; Robert R. Alfano; Alvin Katz, Editor(s)

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