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Proceedings Paper

Determination of the optical properties of vascular tissues: potential applications in vascular-targeting photodynamic therapy
Author(s): Yongbin Tian; Ping Chen; Lie Lin; Zheng Huang; Guoqing Tang; Heping Xu
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Paper Abstract

It has been proven that photodynamic therapy (PDT) is effective in treating various malignant and non-malignant diseases. In the treatment of certain non-malignant vascular diseases, such as wet age-related macular degeneration (AMD) and port wine stains (PWS), unlike in the treatment of malignant solid tumors, light irradiation usually starts immediately after the intravenous (IV) injection of photosensitizers while the photosensitizers is mainly circulating inside blood vessels. Under such vascular-targeting action mode, photoreactions between photosensitizers and light can selectively destruct the vascular tissues. Light distribution is complex so that it is important to understand the optical properties of targeted vessels and surrounding tissues. To better determine the optical properties of vascular tissues, we developed a tissue-simulating phantom and adopted frequency-domain measurement of phase difference. Absorption and reduced scattering coefficients in blood vessels were estimated and light distribution was simulated by the Monte Carlo method. These determinations are essential for the implication of better light dosimetry models in clinical photodynamic therapy and vascular-targeting PDT, in particular.

Paper Details

Date Published: 18 January 2008
PDF: 9 pages
Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68261Q (18 January 2008); doi: 10.1117/12.758255
Show Author Affiliations
Yongbin Tian, Nankai Univ. (China)
Ping Chen, Nankai Univ. (China)
Lie Lin, Nankai Univ. (China)
Zheng Huang, Univ. of Colorado at Denver and Health Sciences Ctr. (United States)
Guoqing Tang, Nankai Univ. (China)
Heping Xu, Thunder Bay Regional Health Sciences Ctr. (Canada)

Published in SPIE Proceedings Vol. 6826:
Optics in Health Care and Biomedical Optics III
Xingde Li; Qingming Luo; Ying Gu M.D., Editor(s)

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