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Proceedings Paper

Multifunctional nanoprobe for biological applications based on surface enhanced Raman scattering
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Paper Abstract

Optical probes are now routinely used in a remarkable number of imaging applications in the life sciences and medicine. We report the design, synthesis and characterization of a novel nanoprobe for biological applications based on surface enhanced Raman scattering (SERS). Specifically, the nanoprobe consists of magnetic Fe3O4 nanoparticles immobilized with silver nanoparticles and SERS tags. An efficient cellular uptake has been confirmed with confocal laser scanning microscopy. The nanoprobe retains its excellent SERS signals when incorporated into a cell. Besides, the probe also delivers spatially localized chemical information from its biological environments. The multi-functional probe is likely to be useful to develop new tools for targeted molecular probing of cells and provide a new way to monitor the complex changes at cellular level.

Paper Details

Date Published: 8 January 2008
PDF: 6 pages
Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68261I (8 January 2008); doi: 10.1117/12.757769
Show Author Affiliations
Zhuyuan Wang, Southeast Univ. (China)
Changgui Lu, Southeast Univ. (China)
Binfeng Yun, Southeast Univ. (China)
Guohua Hu, Southeast Univ. (China)
Yiping Cui, Southeast Univ. (China)


Published in SPIE Proceedings Vol. 6826:
Optics in Health Care and Biomedical Optics III
Xingde Li; Qingming Luo; Ying Gu, Editor(s)

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