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Proceedings Paper

Synthesis and dual fluorescence property of novel dihydroxy phosphorus tetrabenzotriazacorrole derivates
Author(s): Lei Huang; Peng Zhao; Fushi Zhang; Zhongyu Li; Chenho Tung
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Paper Abstract

Photodynamic diagnosis (PDD) is of increasing interest for diagnosis in oncology. It is based on the selective accumulation of photosensitizers in tumours, such as porphyrin and phthalocyanine. In the present study, novel dihydroxy phosphorus tetrabenzotriazacorrole derivates have been synthesized. And photophysical properties of these derivates have been studied. Dihydroxy phosphorus tetrabenzotriazacorrole derivates display a fluorescence which is from the higher S2 electronic state. With excitation at 614 nm, the fluorescence maximum is at 668 nm for dihydroxy phosphorus(V)-2,9,16,23-tetranitrotetrabenzotriazacorrole {P(OH)2TBC(NO2)4} in N,N-dimethylformamide (DMF). But with excitation at 310 nm for P(OH)2TBC(NO2)4 in DMF, in addition to S1 fluorescence a new fluorescence peak appears at 490 nm, which is attributed to S2-state fluorescence. It indicates that the dihydroxy phosphorus tetrabenzotriazacorrole derivates might have a potential application as a dual fluorescent marker for photodynamic diagnosis.

Paper Details

Date Published: 8 January 2008
PDF: 5 pages
Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 68261K (8 January 2008); doi: 10.1117/12.757360
Show Author Affiliations
Lei Huang, Tsinghua Univ. (China)
Peng Zhao, Tsinghua Univ. (China)
Fushi Zhang, Tsinghua Univ. (China)
Zhongyu Li, Tsinghua Univ. (China)
Jilin Institute of Chemical Technology (China)
Chenho Tung, Tsinghua Univ. (China)

Published in SPIE Proceedings Vol. 6826:
Optics in Health Care and Biomedical Optics III
Xingde Li; Qingming Luo; Ying Gu, Editor(s)

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