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Proceedings Paper

An analytic reflection method for time-domain fluorescence diffuse optical tomography based on a generalized pulse spectrum technique
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Paper Abstract

An image reconstruction scheme for time-domain fluorescence diffuse optical tomography is proposed using a reflection-mode for a semi-infinite turbid geometry. The method is based on a generalized pulse spectrum technique that employs analytic expressions of the Laplace-transformed time-domain photon-diffusion model to construct a Born normalized inverse model, and a pair of real domain transform-factors to separate distributions of the fluorescent yield and lifetime. The methodology is validated with a specifically-developed fluorescent Monte-Carlo simulator or finite-element-based methods and its robustness to the background uncertainties is investigated.

Paper Details

Date Published: 12 February 2008
PDF: 8 pages
Proc. SPIE 6850, Multimodal Biomedical Imaging III, 68500M (12 February 2008); doi: 10.1117/12.756377
Show Author Affiliations
Huiyuan He, Tianjin Univ. (China)
Limin Zhang, Tianjin Univ. (China)
Feng Gao, Tianjin Univ. (China)
Zheng Ma, Tianjin Univ. (China)
Huijian Zhao, Tianjin Univ. (China)
Jingying Jiang, Tianjin Univ. (China)


Published in SPIE Proceedings Vol. 6850:
Multimodal Biomedical Imaging III
Fred S. Azar; Xavier Intes, Editor(s)

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