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Proceedings Paper

Improved protein-adsorption resistance of digital microfluidic device via surface coating and structure modification
Author(s): Shun-Yuan Chen; Heng-Cang Hu; Chih-Sheng Yu; Yi-Chiuen Hu
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Paper Abstract

The surface of solid indium tin oxide (ITO) glass supports for samples in electrowetting system needs to be protein-resistant. Since Teflon is the most conventional coating material used to improve the contact angle between the glass and solvent, it still unable to prevent nonspecific proteins adsorption absolutely under the applied potential. In this paper, we described a feasible method that could minimize non-specific proteins adsorption most probably during droplet processing. A regular micro-scale structure was patterned by photolithography, and dielectric layer was covered on the electrodes. Finally a thin layer of Sigmacoat® was coated by physical vapor deposition. The surface characteristic of our chip was analyzed by atomic force microscopy and Contact Angle Analyzer. We found that the adhesion of bio-molecule was efficiently decreased by this modified processing, and could prevent electrolysis more efficiently.

Paper Details

Date Published: 27 December 2007
PDF: 7 pages
Proc. SPIE 6799, BioMEMS and Nanotechnology III, 67991A (27 December 2007); doi: 10.1117/12.755340
Show Author Affiliations
Shun-Yuan Chen, Instrument Technology Research Ctr., National Applied Research Labs. (Taiwan)
Heng-Cang Hu, Instrument Technology Research Ctr., National Applied Research Labs. (Taiwan)
Chih-Sheng Yu, Instrument Technology Research Ctr., National Applied Research Labs. (Taiwan)
Yi-Chiuen Hu, Instrument Technology Research Ctr., National Applied Research Labs. (Taiwan)


Published in SPIE Proceedings Vol. 6799:
BioMEMS and Nanotechnology III
Dan V. Nicolau; Derek Abbott; Kourosh Kalantar-Zadeh; Tiziana Di Matteo; Sergey M. Bezrukov, Editor(s)

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