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Proceedings Paper

In vivo diagnosis of cervical precancer using high wavenumber Raman spectroscopy
Author(s): Jianhua Mo; Wei Zheng; Jeffrey Low; Joseph Ng; A. Ilancheran
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Paper Abstract

Near-infrared (NIR) Raman spectroscopy has shown promise to detect cancer and precancer in human through measuring the biomolecular and biochemical changes of tissue associated with diseases transformation. Most of studies of NIR Raman spectroscopy on tissue diagnosis are concentrated on the so-called fingerprint region (800-1800 cm-1), there are only very limited work for tissue diagnosis using the high wavenumber (2800-3700 cm-1) spectral features. The purpose of this study is to explore the ability of NIR Raman spectroscopy in high wavenumber region for the in vivo detection of cervical precancer. A rapid NIR Raman spectroscopy system associated with a fiber-optic Raman probe was used for the in vivo spectroscopic measurements. Multivariate statistical techniques including principal components analysis (PCA) and linear discriminant analysis (LDA) were employed to develop the diagnostic algorithm based on the spectral data from 2800-3700 cm-1. Classification result based on PCA-LDA showed that high wavenumber NIR Raman spectroscopy can achieve the diagnostic sensitivity of 93.5% and specificity of 95.7% for precancer classification.

Paper Details

Date Published: 18 January 2008
PDF: 5 pages
Proc. SPIE 6826, Optics in Health Care and Biomedical Optics III, 682611 (18 January 2008); doi: 10.1117/12.755265
Show Author Affiliations
Jianhua Mo, National Univ. of Singapore (Singapore)
Wei Zheng, National Univ. of Singapore (Singapore)
Jeffrey Low, National Univ. Hospital and National Univ. of Singapore (Singapore)
Joseph Ng, National Univ. Hospital and National Univ. of Singapore (Singapore)
A. Ilancheran, National Univ. Hospital and National Univ. of Singapore (Singapore)


Published in SPIE Proceedings Vol. 6826:
Optics in Health Care and Biomedical Optics III
Xingde Li; Qingming Luo; Ying Gu, Editor(s)

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