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Proceedings Paper

Laser-optical method of visualization the local net of tissue blood vessels and its biomedical applications
Author(s): M. M. Asimov; R. M. Asimov; A. N. Rubinov
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Paper Abstract

New approach in laser-optical diagnostic methods of cell metabolism based on visualization the local net of tissue blood vessels is proposed. Optical model of laser - tissue interaction and algorithm of mathematical calculation of optical signals is developed. Novel technology of local tissue hypoxia elimination based on laser-induced photodissosiation of oxyhemoglobin in cutaneous blood vessels is developed. Method of determination of oxygen diffusion coefficient into tissue on the base of kinetics of tissue oxygenation TcPO2 under the laser irradiation is proposed. The results of mathematical modeling the kinetic of oxygen distribution into tissue from arterial blood are presented. The possibility of calculation and determination of the level of TcPO2 in zones with the disturbed blood microcirculation is demonstrated. The increase of the value of oxygen release rate more than for times under the irradiation by laser light is obtained. It is shown that the efficiency of laser-induced oxygenation by means of increasing oxygen concentration in blood plasma is comparable with the method of hyperbaric oxygenation (HBO) at the same time gaining advantages in local action. Different biomedical applications of developing method are discussed.

Paper Details

Date Published: 1 August 2007
PDF: 8 pages
Proc. SPIE 6734, International Conference on Lasers, Applications, and Technologies 2007: Laser Technologies for Medicine, 67340S (1 August 2007); doi: 10.1117/12.753264
Show Author Affiliations
M. M. Asimov, Institute of Physics (Belarus)
R. M. Asimov, Applied Systems Ltd. (Belarus)
A. N. Rubinov, Institute of Physics (Belarus)


Published in SPIE Proceedings Vol. 6734:
International Conference on Lasers, Applications, and Technologies 2007: Laser Technologies for Medicine

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