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Proceedings Paper

Application of laser therapy in the treatment of brain ischemia
Author(s): G. A. Zalesskaya; J. I. Musienko; A. V. Kuchinsky
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Paper Abstract

Intravenous laser irradiation of blood (ILIB) by helium-neon laser (HNL) with &lgr;=632.8 nm, 2.5-4.5 mW at the light guide outlet was employed to investigate ILIB influence on blood oxygen transport (BOT), hydro-ion balance for normal rabbits and after modeling of local ischemia of brain (LIB). Marked improvement of disturbances typical for ischemia was revealed for both hydro-ion balance characteristics and BOT parameters such as oxygen tension (pvO2), oxygen hemoglobin saturation (svO2), pvO2 of blood under its 50% saturation by O2 (p50) and tendency was found to their normalization. To identify the molecular photoacceptors and the mechanisms of primary photoreactions the spectral data were used both in visible and infrared regions. On the basis of spectral analysis hemoglobin was discussed as a possible photoacceptor when blood is irradiated with HNL radiation. Variations in the redox properties of respiratory chain components were considered as primary mechanisms of light action on photoacceptor molecules that initiated a cascade of secondary reactions controlling cellular homeostasis parameters.

Paper Details

Date Published: 1 August 2007
PDF: 6 pages
Proc. SPIE 6734, International Conference on Lasers, Applications, and Technologies 2007: Laser Technologies for Medicine, 67341B (1 August 2007); doi: 10.1117/12.753235
Show Author Affiliations
G. A. Zalesskaya, Institute of Molecular and Atomic Physics (Belarus)
J. I. Musienko, Institute of Neurology, Neurosurgery, and Physiotherapy (Belarus)
A. V. Kuchinsky, Institute of Neurology, Neurosurgery, and Physiotherapy (Belarus)


Published in SPIE Proceedings Vol. 6734:
International Conference on Lasers, Applications, and Technologies 2007: Laser Technologies for Medicine

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