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Proceedings Paper

Photophysical properties of photosensitizer chlorin e6 incorporated into polyvinylpyrrolidone
Author(s): M. V. Parkhats; V. N. Knyukshto; H. A. Isakau; P. T. Petrov; B. M. Dzhagarov
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Paper Abstract

It has been demonstrated that chlorin e6 form molecular complex with polyvinylpyrrolidone. The binding constant and the number of binding sites have been determined as Κ= (2.5 ± 0.5)•104 M-1 and N = 2.1 ± 0.5, respectively. Complex in comparison with free chlorin e6 possesses increased fluorescence quantum yield, triplet and singlet state lifetimes, slightly modified intersystem crossing quantum yield, and also more intensive and red shifted absorption band locating in the "phototherapeutic window" of biological tissues. The photophysical properties of chlorin e6 incorporated into the polymer are insensitive to pH. The formation of the complex leads to the disruption of chlorin e6 aggregates at acidic pH. Binding to polymer only slightly improves photophysical properties of photosensitizer and should not provoke fundamental changes in PDT efficiency.

Paper Details

Date Published: 9 July 2007
PDF: 6 pages
Proc. SPIE 6727, ICONO 2007: Nonlinear Laser Spectroscopy and High-Precision Measurements; and Fundamentals of Laser Chemistry and Biophotonics, 67272L (9 July 2007); doi: 10.1117/12.752494
Show Author Affiliations
M. V. Parkhats, Institute of Molecular and Atomic Physics (Belarus)
V. N. Knyukshto, Institute of Molecular and Atomic Physics (Belarus)
H. A. Isakau, RUE Belmedpreparaty (Belarus)
P. T. Petrov, RUE Belmedpreparaty (Belarus)
B. M. Dzhagarov, Institute of Molecular and Atomic Physics (Belarus)


Published in SPIE Proceedings Vol. 6727:
ICONO 2007: Nonlinear Laser Spectroscopy and High-Precision Measurements; and Fundamentals of Laser Chemistry and Biophotonics

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