Share Email Print
cover

Proceedings Paper

Absorption spectrum characteristic of chorophyll derivatives photosensitizer CPD3
Author(s): Fenghua Xiang; Hui Liu; Youshan Lu; Ping Chen; Guoqing Tang
Format Member Price Non-Member Price
PDF $14.40 $18.00
cover GOOD NEWS! Your organization subscribes to the SPIE Digital Library. You may be able to download this paper for free. Check Access

Paper Abstract

Absorption spectrum of CPD3 is determined. There are two absorption bands all in absorption spectrum, the maximal absorption of band B is at 395nm in 0.9% NaCl solution and TE buffer solution, the band Q is locating at 677nm and 651nm respectively in solvents above. The order of magnitude of extinction coefficient is 104 in both solvents. the absorption peak of CPD3-DNA mix solution have 6nm and 23nm red shift for band B and band Q respectively compared with pure CPD3 in 0.9% NaCl solution, this indicates that interaction between photosensitizer and DNA occurring. Time series data of absorption for CPD3-DNA mix solution supports the interaction viewpoint further, and the full action time is about 90mins. The type of interaction needs a further investigating. Stronger absorption in red region and the interaction with DNA suggests that CPD3 will have a bright future in photodynamic therapy.

Paper Details

Date Published: 1 May 2007
PDF: 6 pages
Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 653425 (1 May 2007); doi: 10.1117/12.741634
Show Author Affiliations
Fenghua Xiang, Nankai Univ. (China)
Langfang Normal College (China)
Hui Liu, Tianjin Quality Supervision and Inspection Ctr. for Medical Devices (China)
Youshan Lu, Tianjin Quality Supervision and Inspection Ctr. for Medical Devices (China)
Ping Chen, Nankai Univ. (China)
Guoqing Tang, Nankai Univ. (China)


Published in SPIE Proceedings Vol. 6534:
Fifth International Conference on Photonics and Imaging in Biology and Medicine

© SPIE. Terms of Use
Back to Top