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Proceedings Paper

Spontaneous generation and disappearance of burst firing in cultured neuronal network
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Paper Abstract

Burst as a unit of information coding is widely investigated in the developing central nervous system. However the mechanism underling the bursts generate and disappear is unclear at present. Neurons cultured on the multi-electrode arrays, are spontaneously active, and show complex pattern with random spikes and bursts firing. With long-term recording, the course of bursts generation and disappearance was detected. The results showed that the firing pattern could transform from random spikes to bursts firing. In the beginning, the random spikes rate decreased, accompanied with bursts occurred once in a while. It appeared both single spikes and bursts at the same time. After that, the random spikes disappeared. Spontaneous activity displayed a regular occurrence of bursts with shorter interspike interval. During such bursts the firing rate at the active sites was increased dramatically. After several seconds, firing rate decreased, interburst interval extended, accompanied with the occurrence of random spikes, opposite to the beginning. At last, bursts disappeared and the networks just fired in random spikes. The observation showed that the complex electrophysiological activities of the cultured neuronal networks could implicate the spontaneous generation of burst firing. Understanding how bursts generate and disappear might be significant for deeply investigating the function and mechanism of bursts information coding.

Paper Details

Date Published: 1 May 2007
PDF: 4 pages
Proc. SPIE 6534, Fifth International Conference on Photonics and Imaging in Biology and Medicine, 65343F (1 May 2007); doi: 10.1117/12.741468
Show Author Affiliations
Man Liu, The Key Lab. of Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Wei Zhou, The Key Lab. of Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Xiangning Li, The Key Lab. of Biomedical Photonics, Huazhong Univ. of Science and Technology (China)
Qingming Luo, The Key Lab. of Biomedical Photonics, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 6534:
Fifth International Conference on Photonics and Imaging in Biology and Medicine

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