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Proceedings Paper

Diffusion of Cortexin and Retinalamin in eye sclera
Author(s): Elina A. Genina; Elena A. Zubkova; Anastasiya A. Korobko; Irina Yu. Yanina; Alexey N. Bashkatov; Tatyana G. Kamenskikh; Vladimir A. Galanzha; Valery V. Tuchin
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Paper Abstract

Spectral measurements of sclera reflectance during its interaction with aqueous solutions of both Cortexin and Retinalamin have been carried out. Twenty three samples included in the study were human sclera and rabbit sclera in vitro. The results of the experiments have shown that penetration of Cortexin as well as Retinalamin into sclera tissue leads to the decrease of sclera reflection due to optical immersion. Estimation of diffusion coefficients of studied solutions was made on the basis of analysis of reflectance change dynamics of the sclera samples. Diffusion coefficients of Cortexin and Retinalamin in sclera tissue were estimated as (4.4±2.7)x10-6 and (1.82±0.14)x10-6 cm2/sec, respectively. Obtained values of diffusion coefficient allowed estimating time needed for total penetration of both agents through scleral membrane at subtenon's injection of studied agents. The results are important for treatment of partial optic atrophy observed at primary open-angle glaucoma and others eye diseases.

Paper Details

Date Published: 26 April 2007
PDF: 6 pages
Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65351Y (26 April 2007); doi: 10.1117/12.741082
Show Author Affiliations
Elina A. Genina, Saratov State Univ. (Russia)
Elena A. Zubkova, Saratov State Univ. (Russia)
Anastasiya A. Korobko, Saratov State Univ. (Russia)
Irina Yu. Yanina, Saratov State Univ. (Russia)
Alexey N. Bashkatov, Saratov State Univ. (Russia)
Tatyana G. Kamenskikh, Saratov State Medical Univ. (Russia)
Vladimir A. Galanzha, Saratov State Medical Univ. (Russia)
Valery V. Tuchin, Saratov State Univ. (Russia)

Published in SPIE Proceedings Vol. 6535:
Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII

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