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Proceedings Paper

Gross protein influence upon blood plasma and serum self organization processes in patients with coronary heart disease
Author(s): Lidia I. Malinova; Uliya V. Sergeeva; Georgy V. Simonenko; Tatiana P. Denisova; Valery V. Tuchin
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Paper Abstract

Blood plasma pattern formation is a process sensitive to environment and carrier properties, and plasma biochemical content. 96 patients with coronary heart disease (CHD) were involved in the study. Control group include 12 practically health persons (PHP). Platelets poor plasma and serum were used to study functional morphology. Plasma and serum samples of equal volume were placed on degreased glass carrier with after going wedge dehydration. The result of wedge dehydration is a formation of a special structure called facia. To the samples of compare albumin solution was added. Morphology of prepared facies was studied by means of light microscopy ("Lomo Biolam P2-1") with 10 times magnification. All received facies were of the same principle structure with central, intermediate and edge zones. Zone index was increasing in samples with albumin adding. Special structures obligatory to atherosclerosis, vessels stiffness increase and hypoxia were found in facies of plasma and serum of patients with CHD. Quantity of these structures correlated to protein concentration (p = 0.021). Samples' drying period was also increasing in samples of compare, and differed significantly in patients with CHD and PHP. In our study gross proteins concentration increase modified plasma and serum morphology. Albumin solution can be proposed as a probe to elucidate differences of facies of patients with CHD and PHP.

Paper Details

Date Published: 26 April 2007
PDF: 5 pages
Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65351W (26 April 2007); doi: 10.1117/12.741012
Show Author Affiliations
Lidia I. Malinova, Saratov Scientific Research Institute of Cardiology (Russia)
Saratov State Medical Univ. (Russia)
Uliya V. Sergeeva, Saratov State Medical Univ. (Russia)
Georgy V. Simonenko, Saratov State Univ. (Russia)
Tatiana P. Denisova, Saratov State Medical Univ. (Russia)
Valery V. Tuchin, Saratov State Univ. (Russia)

Published in SPIE Proceedings Vol. 6535:
Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII
Valery V. Tuchin, Editor(s)

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