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Proceedings Paper

Blood flow structure in patients with coronary heart disease
Author(s): Lidia I. Malinova; Georgy V. Simonenko; Tatyana P. Denisova; Valery V. Tuchin
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Paper Abstract

Blood flow structure was studied by PC integrated video camera with following slide by slide analysis. Volumetric blood flow velocity was supporting on constant level (1 ml/h). Silicone tube of diameter comparable with coronary arteries diameter was used as vessel model. Cell-cell interactions were studied under glucose and anticoagulants influence. Increased adhesiveness of blood cells to tube walls was revealed in patient with coronary heart disease (CHD) compare to practically healthy persons (PHP). In patients with stable angina pectoris of high functional class and patients with AMI shear stress resistant erythrocyte aggregates were predominating in blood flow structure up to microclots formation. Clotting and erythrocytes aggregation increase as response to glucose solution injection, sharply defined in patients with CHD. Heparin injection (10 000 ED) increased linear blood flow velocity both in patients with CHD and PHP. After compare our results with other author's data we can consider that method used in our study is sensible enough to investigate blood flow structure violations in patients with CHD and PHP. Several differences of cell-cell interaction in flow under glucose and anticoagulant influence were found out in patients with CHD and PHP.

Paper Details

Date Published: 26 April 2007
PDF: 6 pages
Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65351V (26 April 2007); doi: 10.1117/12.741011
Show Author Affiliations
Lidia I. Malinova, Saratov Scientific Research Institute of Cardiology (Russia)
Saratov State Medical Univ. (Russia)
Georgy V. Simonenko, Saratov State Univ. (Russia)
Tatyana P. Denisova, Saratov State Medical Univ. (Russia)
Valery V. Tuchin, Saratov State Univ. (Russia)

Published in SPIE Proceedings Vol. 6535:
Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII
Valery V. Tuchin, Editor(s)

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