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Proceedings Paper

In vitro study of indocyanine green solution interaction with skin
Author(s): Elina A. Genina; Marina Yu. Kuzmina; Stanislav S. Pankov; Alexey N. Bashkatov; Valery V. Tuchin
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Paper Abstract

Absorption properties of Indocyanine Green (ICG) dissolved in both water and 40%-ethanol for potential using in laser selective thermolysis have been researched. Correlation between magnitudes and positions of absorption bands of ICG in dependence on the kind of solvent and concentration of ICG has been studied. Interaction between ICG solutions and rat skin in vitro has been investigated. Shift of the main absorption peaks of ICG solutions in skin has been defined. Such shift is caused by ICG interaction with protein molecules of the stratum corneum and dermis. Diffusion coefficients of ICG in skin have been estimated at diffusion of aqueous solutions through dermis and at diffusion of alcohol solutions through both dermis and epidermis as (7.70±2.51)×10-7, (18.79±3.35)×10-7 and (6.85±3.75)×10-7, respectively.

Paper Details

Date Published: 26 April 2007
PDF: 10 pages
Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65351H (26 April 2007); doi: 10.1117/12.740992
Show Author Affiliations
Elina A. Genina, Saratov State Univ. (Russia)
Marina Yu. Kuzmina, Saratov State Univ. (Russia)
Stanislav S. Pankov, Saratov State Univ. (Russia)
Alexey N. Bashkatov, Saratov State Univ. (Russia)
Valery V. Tuchin, Saratov State Univ. (Russia)

Published in SPIE Proceedings Vol. 6535:
Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII

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