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Investigation of skin water loss and glycerol delivery through stratum corneum
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Paper Abstract

Investigation of skin water loss and clearing agent delivery through stratum corneum is presented. Effectiveness of the method "lattice of islets of damage" for enhancement of stratum corneum permeability for water and 71% glycerol solution providing the skin clearing was investigated. Dehydration induced by both stimuli evaporation and osmotic agent action was studied by weight measurements. Measurements of refractive index dynamics of glycerol and water during its interaction with skin samples were carried out. The results have shown that proposed method allows effective transepidermal water loss and delivery of optical clearing agents.

Paper Details

Date Published: 26 April 2007
PDF: 8 pages
Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65351G (26 April 2007); doi: 10.1117/12.740990
Show Author Affiliations
Elina A. Genina, Saratov State Univ. (Russia)
Anastasiya A. Korobko, Saratov State Univ. (Russia)
Alexey N. Bashkatov, Saratov State Univ. (Russia)
Valery V. Tuchin, Saratov State Univ. (Russia)
Ilya V. Yaroslavsky, Palomar Medical Products (United States)
Gregory B. Altshuler, Palomar Medical Products (United States)

Published in SPIE Proceedings Vol. 6535:
Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII
Valery V. Tuchin, Editor(s)

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