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Proceedings Paper

Laser microinterferometer for estimation of red blood cell volume
Author(s): Grigory Lazarev; Alexander Sedashev
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Paper Abstract

Phase contrast and interference microscopes are widely used for microbiological and biomedical research. However most of them can't give high precision quantitative estimation of cell volume and morphology due to modest resolution. We propose scheme based on a modified laser Linnik microinterferometer providing high both phase and spatial resolutions. Red blood cell volume is calculated using integration of phase height distribution; limits of integration are determined by Canny edge detection procedure. Experimental volume estimation fits well to volume data obtained with other methods.

Paper Details

Date Published: 2 May 2007
PDF: 7 pages
Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 653516 (2 May 2007); doi: 10.1117/12.740975
Show Author Affiliations
Grigory Lazarev, Bauman Moscow State Technical Univ. (Russia)
Alexander Sedashev, Bauman Moscow State Technical Univ. (Russia)


Published in SPIE Proceedings Vol. 6535:
Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII

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