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Proceedings Paper

Monitor glucose induced changes in optical properties of rat skin in vitro
Author(s): Dan Zhu; Wei Lu; Qin Li; Hui Gong; Qingming Luo
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Paper Abstract

Optical clearing technique of tissue most goes to qualitative analysis, it is more important to get the quantitative optical properties of tissue. A self-developed local measuring system had been used to monitor the dynamics of optical properties of rat skin under 30mins treatment with 40% glucose, and then 30 min recovery with saline. The thickness of native, and the end of two different administration stages were measured. The results show that, in 30 minutes' treatment of 40% glucose, tissue optical properties decreased. This change was very big in the first minute and reached a plateau after 25 minutes. The absorption coefficient, scattering coefficient and the sample thickness reduced to 88.6%, 71%, 85% of the original value, respectively. It may be that the glucose solution induced a dehydration process of skin. After the saline treatment, the three parameters of the tissue recovered to 96%, 94%, 90% of the original value, respectively. This result proved that the 40% glucose administration stage on the tissue properties is reversible.

Paper Details

Date Published: 26 April 2007
PDF: 6 pages
Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65350P (26 April 2007); doi: 10.1117/12.740956
Show Author Affiliations
Dan Zhu, Huazhong Univ. of Science and Technology (China)
Wei Lu, Huazhong Univ. of Science and Technology (China)
Qin Li, Huazhong Univ. of Science and Technology (China)
Hui Gong, Huazhong Univ. of Science and Technology (China)
Qingming Luo, Huazhong Univ. of Science and Technology (China)


Published in SPIE Proceedings Vol. 6535:
Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII

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