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Proceedings Paper

Quantitative tissue polarimetry using polar decomposition of 3 x 3 Mueller matrix
Author(s): M. K. Swami; S. Manhas; P. Buddhiwant; N. Ghosh; A. Uppal; P. K. Gupta
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Paper Abstract

Polarization properties of any optical system are completely described by a sixteen-element (4 x 4) matrix called Mueller matrix, which transform the Stokes vector describing the polarization properties of incident light to the stokes vector of scattered light. Measurement of all the elements of the matrix requires a minimum of sixteen measurements involving both linear and circularly polarized light. However, for many diagnostic applications, it would be useful if all the polarization parameters of the medium (depolarization (Δ), differential attenuation of two orthogonal polarizations, that is, diattenuation (d), and differential phase retardance of two orthogonal polarizations, i.e., retardance (δ )) can be quantified with linear polarization measurements alone. In this paper we show that for a turbid medium, like biological tissue, where the depolarization of linearly polarized light arises primarily due to the randomization of the field vector's direction by multiple scattering, the polarization parameters of the medium can be obtained from the nine Mueller matrix elements involving linear polarization measurements only. Use of the approach for measurement of polarization parameters (Δ, d and δ) of normal and malignant (squamous cell carcinoma) tissues resected from human oral cavity are presented.

Paper Details

Date Published: 26 April 2007
PDF: 8 pages
Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65350J (26 April 2007); doi: 10.1117/12.740806
Show Author Affiliations
M. K. Swami, Raja Ramanna Ctr. for Advanced Technology (India)
S. Manhas, Raja Ramanna Ctr. for Advanced Technology (India)
P. Buddhiwant, Raja Ramanna Ctr. for Advanced Technology (India)
N. Ghosh, Raja Ramanna Ctr. for Advanced Technology (India)
A. Uppal, Raja Ramanna Ctr. for Advanced Technology (India)
P. K. Gupta, Raja Ramanna Ctr. for Advanced Technology (India)


Published in SPIE Proceedings Vol. 6535:
Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII
Valery V. Tuchin, Editor(s)

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