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Proceedings Paper

Monitoring changes in the scattering properties of mouse skin with optical coherence tomography during an in vivo glucose tolerance test
Author(s): M. Kinnunen; S. Tausta; R. Myllylä; S. Vainio
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Paper Abstract

A non-invasive glucose monitoring technique would make evaluation of blood glucose values easier and more convenient. This would help diabetic patients to control their blood glucose values more regularly. A few years ago optical coherence tomography (OCT) was proposed as a non-invasive sensor for monitoring changes in blood glucose concentration. The method is based on monitoring glucose-induced changes in the scattering properties of the target. This article describes how OCT was used to monitor changes in the scattering properties of mouse skin during an in vivo glucose tolerance test. The results show that OCT has the potential to register glucose-induced changes in the optical properties of the sample. However, a commercial OCT device with a probe designed for imaging is not very suitable for non-invasive monitoring of glucose-induced changes in scattering. The problems confronted in this study, possibly originating from the small size of the animals, are discussed in the article.

Paper Details

Date Published: 26 April 2007
PDF: 10 pages
Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65350B (26 April 2007); doi: 10.1117/12.740621
Show Author Affiliations
M. Kinnunen, Univ. of Oulu (Finland)
S. Tausta, Univ. of Oulu (Finland)
R. Myllylä, Univ. of Oulu (Finland)
S. Vainio, Univ. of Oulu (Finland)


Published in SPIE Proceedings Vol. 6535:
Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII

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