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Proceedings Paper

Activelets and sparsity: a new way to detect brain activation from fMRI data
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Paper Abstract

FMRI time course processing is traditionally performed using linear regression followed by statistical hypothesis testing. While this analysis method is robust against noise, it relies strongly on the signal model. In this paper, we propose a non-parametric framework that is based on two main ideas. First, we introduce a problem-specific type of wavelet basis, for which we coin the term "activelets". The design of these wavelets is inspired by the form of the canonical hemodynamic response function. Second, we take advantage of sparsity-pursuing search techniques to find the most compact representation for the BOLD signal under investigation. The non-linear optimization allows to overcome the sensitivity-specificity trade-off that limits most standard techniques. Remarkably, the activelet framework does not require the knowledge of stimulus onset times; this property can be exploited to answer to new questions in neuroscience.

Paper Details

Date Published: 27 September 2007
PDF: 8 pages
Proc. SPIE 6701, Wavelets XII, 67010Y (27 September 2007); doi: 10.1117/12.734706
Show Author Affiliations
Ildar Khalidov, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Dimitri Van De Ville, Ecole Polytechnique Fédérale de Lausanne (Switzerland)
Jalal Fadili, ENSI Caen (France)
Michael Unser, Ecole Polytechnique Fédérale de Lausanne (Switzerland)


Published in SPIE Proceedings Vol. 6701:
Wavelets XII
Dimitri Van De Ville; Vivek K. Goyal; Manos Papadakis, Editor(s)

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