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Proceedings Paper

Cytotoxicity of the photoluminescent silicon nanocrystals
Author(s): Jonghoon Choi; Qin Zhang; Victoria M. Hitchins; Nam Sun Wang; Vytas Reipa
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Paper Abstract

Biocompatibility of photoluminescent silicon nanocrystals was tested using standard cytotoxicity protocols with murine macrophage cell line RAW 264.7. We investigated the cytotoxicity and inflammatory responses of cells exposed to silicon nanocrystals by several biological endpoints. Cell death ratio, morphological changes, and the levels of nitric oxide production were studied. Spatial position of the nanoparticles relative to cell body was investigated using fluorescent microscopy. No statistically significant cytotoxicity or inflammatory response was detected with autoclaved silicon nanoparticles at concentrations up to 20 μg/ml in RAW 264.7 cells. The present study of murine macrophages, exposed to autoclaved silicon nanocrystals, will help define safety requirements for comparable nanoparticle biomedical applications.

Paper Details

Date Published: 11 September 2007
PDF: 8 pages
Proc. SPIE 6645, Nanoengineering: Fabrication, Properties, Optics, and Devices IV, 66451Q (11 September 2007); doi: 10.1117/12.734222
Show Author Affiliations
Jonghoon Choi, Univ. of Maryland, College Park (United States)
National Institute of Standards and Technology (United States)
U.S. Food and Drug Administration (United States)
Qin Zhang, U.S. Food and Drug Administration (United States)
Victoria M. Hitchins, U.S. Food and Drug Administration (United States)
Nam Sun Wang, Univ. of Maryland, College Park (United States)
Vytas Reipa, National Institute of Standards and Technology (United States)


Published in SPIE Proceedings Vol. 6645:
Nanoengineering: Fabrication, Properties, Optics, and Devices IV
Elizabeth A. Dobisz; Louay A. Eldada, Editor(s)

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