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Proceedings Paper

Laser effect in photodynamic therapy of tumors
Author(s): Rodica-Mariana Ion; Dragos-Viorel Brezoi; Monica Neagu; Gina Manda; Carolina Constantin
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Paper Abstract

Photodynamic therapy is a method that provides a reasonable alternative to other treatment modalities for patients with certain cancers, and in some cases may be the preferred treatment. The therapy implies the intravenous administration of a light-sensitive substance, the photosensitizer. The used sensitizer must absorb at long wavelength. For these purposes, the carbon dioxide laser, He-Ne and the argon laser are particularly suitable. In this study we evaluate in vitro the cytotoxic activity of three synthesized metallo-phthalocyanines with absorption bands in the red part of the spectrum: zinc-di-sulphonated phthalocyanine (ZnS2Pc), zinc-tri-sulphonated phthalocyanine (ZnS3Pc) and zinc-tetrasulphonated phthalocyanine (ZnS4Pc). Some cellular models have been used in this paper, in order to optimize the conditions of this method, as we are presenting in this paper (LSR-SF(SR) - transplantable sarcoma in rat induced by Rous sarcoma virus strain Schmidt-Ruppin; LSCC-SF(Mc29) - transplantable chicken hepatoma induced by the myelocytomatosis virus Mc29, MCF-7 cell line (human breast adenocarcinoma) derived from a patient with metastatic breast cancer, 8-MG-BA - glioblastoma multiforme 8-MG-BA, K562 - lymphoblastic human cell line, LLC-WRC 256 - Walker epithelial carcinoma. Activation of these photosensitizers retained in the cancerous cells, by red light emitted from a He-Ne laser at &lgr;= 632.8 nm laser system, or by a diode laser emitting at 672 nm, produces a photochemical reaction that results in the selective destruction of tumor cells.

Paper Details

Date Published: 25 April 2007
PDF: 9 pages
Proc. SPIE 6606, Advanced Laser Technologies 2006, 66061G (25 April 2007); doi: 10.1117/12.730203
Show Author Affiliations
Rodica-Mariana Ion, Valahia Univ. (Romania)
National Institute for Chemical and Petrochemical Research (Romania)
Dragos-Viorel Brezoi, Valahia Univ. (Romania)
Monica Neagu, Victor Babes National Institute (Romania)
Gina Manda, Victor Babes National Institute (Romania)
Carolina Constantin, Victor Babes National Institute (Romania)


Published in SPIE Proceedings Vol. 6606:
Advanced Laser Technologies 2006

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