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Proceedings Paper

Stochastic trigger for clathrin-coated vesicle biogenesis
Author(s): Ralph Nossal
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Paper Abstract

Kinetic aspects of receptor-mediated endocytosis are identified, particularly as relating to the stochastic formation and released of clathrin coated vesicles at the plasma membrane. We discuss how one might account for the coordinated steps of this process, including receptor activation, association with adaptor proteins, coat formation, and the role of phosphoinosotide metabolism as a regulatory mechanism. In anticipation of building a detailed mathematical theory, we discuss an earlier treatment of the way threshold fluctuations affect the firing probability of nerve axons (H. Lecar, and R. Nossal, Biophys. J. 11, pp. 1048--1067, 1971), in which equations were analyzed by distinguishing different time-scales to identify pertinent kinetic variables

Paper Details

Date Published: 5 June 2007
PDF: 12 pages
Proc. SPIE 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, 66020J (5 June 2007); doi: 10.1117/12.729597
Show Author Affiliations
Ralph Nossal, National Institutes of Health (United States)


Published in SPIE Proceedings Vol. 6602:
Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems
Sergey M. Bezrukov, Editor(s)

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