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Proceedings Paper

Quantification of the outer retinal layers: correlation to visual acuity in healthy subjects and patients with central serous chorioretinopathy
Author(s): Birgit Sander; Ulrik Christensen; Michael Larsen; Thomas M. Jørgensen
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Paper Abstract

Purpose: Quantification of outer retinal layers in humans. Method: 11 eyes in healthy subjects and 3 eyes in patients after resolution of central serous chorioretinopathy (CSCR). Multiple line scans were obtained using OCT Stratus and scans were registered and averaged to enhance contrast. The distance from the inner-outer segment junction to the posterior part of the retinal pigment epithelium (RPE-OScomplex) was calculated. In addition, the reflectance of the outer photoreceptor layer in the foveal center was compared to that peripheral to the fovea. Results: Mean thickness of the RPE-OScomplex in healthy subjects was 77.3 μm, in CSCR 52.9 μm. The thickness of the RPE-OScomplex was significantly correlated to visual acuity (r=0.95, p<0.01). The ratio of reflectance (fovea/parafovea) was 1.06 in healthy subjects, 1.18 in CSCR eyes. Conclusion: The RPE-OScomplex thickness was markedly reduced in eyes after resolution of CSCR and highly correlated to the visual acuity, the correlation to total foveal thickness was less. An increased backscatter was seen in CSCR, probably due to photoreceptor disorganization and atrophy.

Paper Details

Date Published: 11 July 2007
PDF: 7 pages
Proc. SPIE 6627, Optical Coherence Tomography and Coherence Techniques III, 66271M (11 July 2007); doi: 10.1117/12.729548
Show Author Affiliations
Birgit Sander, Glostrup Hospital (Denmark)
Ulrik Christensen, Copenhagen Univ. Hospital Glostrup (Denmark)
Michael Larsen, Copenhagen Univ. Hospital Glostrup (Denmark)
Thomas M. Jørgensen, Technical Univ. of Denmark (Denmark)


Published in SPIE Proceedings Vol. 6627:
Optical Coherence Tomography and Coherence Techniques III
Peter E. Andersen; Zhongping Chen, Editor(s)

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