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Proceedings Paper

High throughput high content live cell screening platform
Author(s): Rainer Uhl; Rainer Daum; Hartmann Harz; Christian Seebacher; Schomiron Neogy
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Paper Abstract

The goal was to develop a light-microscope platform concept, which allows characterization of live cells in microtiter plates or in live-cell slide chambers with a speed, sensitivity and versatility unattainable so far. The goal was achieved by combining several novel technological concepts: a model-based digital control for a voice coil focus drive; scanner technology to follow a continuously moving sample during image acquisition, thus avoiding the usual stop-and-go; fast sectioning capabilities by using slit-scan confocal concepts; motorized dual emission image registration; and integrated environmental control.

Paper Details

Date Published: 13 July 2007
PDF: 12 pages
Proc. SPIE 6633, Biophotonics 2007: Optics in Life Science, 66330C (13 July 2007); doi: 10.1117/12.729545
Show Author Affiliations
Rainer Uhl, Ludwig-Maximilians-Univ. München (Germany)
TILL Photonics GmbH (Germany)
Rainer Daum, TILL Photonics GmbH (Germany)
Hartmann Harz, Ludwig-Maximilians-Univ. München (Germany)
Christian Seebacher, Ludwig-Maximilians-Univ. München (Germany)
Schomiron Neogy, Ludwig-Maximilians-Univ. München (Germany)
TILL I.D. GmbH (Germany)


Published in SPIE Proceedings Vol. 6633:
Biophotonics 2007: Optics in Life Science
Jürgen Popp; Gert von Bally, Editor(s)

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