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Proceedings Paper

Silicon nanocrystals as efficient photosensitizer of singlet oxygen for biomedical applications
Author(s): V. Yu. Timoshenko; L. A. Osminkina; A. S. Vorontsov; Yu. V. Ryabchikov; M. B. Gongalsky; A. I. Efimova; E. A. Konstantinova; T. Yu. Bazylenko; P. K. Kashkarov; A. A. Kudriavtsev
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Paper Abstract

Luminescent silicon nanocrystals (nc-Si) are shown to be efficient photosensitizers of singlet oxygen (SO) generation. Photoluminescence (PL) spectroscopy method is used to study the mechanism and efficiency of the SO photosensitization in gaseous and aqueous ambiences. In vitro experiments demonstrated that the SO, photosensitized by nc-Si dispersed in nutrient solutions, could kill cancer cells. This finding opens a broad opportunity for biomedical applications of nc-Si, e.g. for the photodynamic therapy of cancer or antibacterial treatments.

Paper Details

Date Published: 25 April 2007
PDF: 4 pages
Proc. SPIE 6606, Advanced Laser Technologies 2006, 66061E (25 April 2007); doi: 10.1117/12.729523
Show Author Affiliations
V. Yu. Timoshenko, M.V. Lomonosov Moscow State Univ. (Russia)
L. A. Osminkina, M.V. Lomonosov Moscow State Univ. (Russia)
A. S. Vorontsov, M.V. Lomonosov Moscow State Univ. (Russia)
Yu. V. Ryabchikov, M.V. Lomonosov Moscow State Univ. (Russia)
M. B. Gongalsky, M.V. Lomonosov Moscow State Univ. (Russia)
A. I. Efimova, M.V. Lomonosov Moscow State Univ. (Russia)
E. A. Konstantinova, M.V. Lomonosov Moscow State Univ. (Russia)
T. Yu. Bazylenko, M.V. Lomonosov Moscow State Univ. (Russia)
P. K. Kashkarov, M.V. Lomonosov Moscow State Univ. (Russia)
A. A. Kudriavtsev, Institute of Theoretical and Experimental Biophysics (Russia)


Published in SPIE Proceedings Vol. 6606:
Advanced Laser Technologies 2006
Dan C. Dumitras; Maria Dinescu; Vitally I. Konov, Editor(s)

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