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Proceedings Paper

Luminescent nanoparticles for molecular medicine
Author(s): V. Weiler; M. Haase; C. Walter; W. Hoheisel; H. Hummel
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Paper Abstract

Novel optical labels based on nanophosphor materials like LaPO4:Ce,Tb and CePO4:Tb-LaPO4 core-shell nanophosphors were presented. Core particles could be synthesised smaller than 10nm and stabilized in aqueous media. Polymer coatings of individual nanoparticles increased long term stability and introduced functional groups of interest for bioconjugation chemistry. A new strategy for conjugation of bioligands via His-tags was given. In feasibility studies for in-vitro diagnostic applications these dnanophosphors featured their advantage over organic dyes. As an example the detection of hybridization and thermal induced denaturation events of DNA strands read out by FRET processes was presented.

Paper Details

Date Published: 13 July 2007
PDF: 7 pages
Proc. SPIE 6633, Biophotonics 2007: Optics in Life Science, 66332J (13 July 2007); doi: 10.1117/12.729472
Show Author Affiliations
V. Weiler, Philips Technologie GmbH Forschungslaboratorien (Germany)
M. Haase, Univ. of Osnabrueck (Germany)
C. Walter, Univ. of Osnabrueck (Germany)
W. Hoheisel, Bayer Technology Services GmbH (Germany)
H. Hummel, Philips Technologie GmbH Forschungslaboratorien (Germany)

Published in SPIE Proceedings Vol. 6633:
Biophotonics 2007: Optics in Life Science
Jürgen Popp; Gert von Bally, Editor(s)

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