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Proceedings Paper

Near-surface sensitivity suppression way for diffuse reflective optical tomography: simulation and a phantom study
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Paper Abstract

Diffuse reflective optical measurement is a useful approach for monitoring the oxygen consumption of living tissue such as brain and muscle. To improve the oxygen consumption measurement accuracy, we propose a method for suppressing the near-surface sensitivity. Diffuse reflective light is detected at the aperture used for irradiating the light and is used as a cancellation signal for near-field sensitivity in the conventional measurement scheme. Photon fluence density functions and positional dependences of detected light sensitivity to change in absorbance were simulated. The sensitivity detected at the same position (aperture) as irradiation was significantly high for the near-surface region. With our method, the near-surface sensitivity is reduced by more than 90% while keeping target sensitivity almost constant (only 3% deterioration). The near-surface and deep-field sensitivity was measured with a phantom with light (785 nm) modulated at 1 kHz through an optical fiber bundle. It confirmed suppressed the near-surface sensitivity by subtracting the light detected at the same aperture from the light detected at another aperture.

Paper Details

Date Published: 12 July 2007
PDF: 8 pages
Proc. SPIE 6629, Diffuse Optical Imaging of Tissue, 662907 (12 July 2007); doi: 10.1117/12.729461
Show Author Affiliations
Keiko Fukuda, Tokyo Metropolitan College of Industrial Technology (Japan)
Mamiko Fujii, Sophia Univ. (Japan)

Published in SPIE Proceedings Vol. 6629:
Diffuse Optical Imaging of Tissue
Brian W. Pogue; Rinaldo Cubeddu, Editor(s)

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