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Proceedings Paper

Semi-analytical method for rapid calculation of time-resolved reflectance from bi-layered tissue models
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Paper Abstract

Photon transport in complex biological tissues is most accurately predicted via Monte Carlo (MC) modeling methods, which often require lengthy computation times. In this report, a semi-analytical technique (henceforth referred to as PI-scaling) was derived that combines MC simulation, absorption scaling, and path integrals (PI) to rapidly reconstruct time-resolved reflectance from the surface of bilayered epithelial tissue models. Comparisons to forward MC simulations indicated that the PI−scaling method was accurate to better than 10% for tissue models where the optical properties of the top layer did not greatly influence the time-resolved reflectance. Employing such a method should provide a novel solution to the first step of the problem of rapid simulation of time-resolved reflectance of photons in layered tissues.

Paper Details

Date Published: 19 July 2007
PDF: 10 pages
Proc. SPIE 6628, Diagnostic Optical Spectroscopy in Biomedicine IV, 66280W (19 July 2007); doi: 10.1117/12.729431
Show Author Affiliations
Robert H. Wilson, Univ. of Michigan (United States)
Karthik Vishwanath, Duke Univ. (United States)
Mary-Ann Mycek, Univ. of Michigan (United States)


Published in SPIE Proceedings Vol. 6628:
Diagnostic Optical Spectroscopy in Biomedicine IV
Dietrich Schweitzer; Maryann Fitzmaurice, Editor(s)

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