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Proceedings Paper

Interferometric optical online dosimetry for selective retina treatment (SRT)
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Paper Abstract

Selective retina treatment (SRT) is a new laser based method to treat retinal diseases associated with disorders of the retinal pigment epithelium (RPE). Applying microsecond laser pulses tissue damage spatially confined to the retinal pigment epithelium (RPE) is achieved. The RPE cell damage is caused by transient microbubbles emerging at the strongly absorbing melanin granules inside the RPE cells. Due to the spatial confinement to the RPE the photoreceptors can be spared and vision can be maintained in the treated retinal areas. A drawback for effective clinical SRT is that the laser induced lesions are ophthalmoscopically invisible. Therefore, a real-time feedback system for dosimetry is necessary in order to avoid undertreatment or unwanted collateral damage to the adjacent tissue. We develop a dosimetry system which uses optical interferometry for the detection of the transient microbubbles. The system is based on an optical fiber interferometer operated with a laser diode at 830nm. We present current results obtained with a laser slit lamp using porcine RPE explants in vitro and complete porcine eye globes ex vivo. The RPE cell damage is determined by Calcein fluorescence viability assays. With a threshold criterium for RPE cell death derived from the measured interferometric signal transients good agreement with the results of the viability assays is achieved.

Paper Details

Date Published: 13 July 2007
PDF: 8 pages
Proc. SPIE 6632, Therapeutic Laser Applications and Laser-Tissue Interactions III, 663219 (13 July 2007); doi: 10.1117/12.728460
Show Author Affiliations
Hardo Stoehr, Institute of Biomedical Optics, Univ. of Lübeck (Germany)
Lars Ptaszynski, Institute of Biomedical Optics, Univ. of Lübeck (Germany)
Andreas Fritz, Institute of Biomedical Optics, Univ. of Lübeck (Germany)
Ralf Brinkmann, Institute of Biomedical Optics, Univ. of Lübeck (Germany)


Published in SPIE Proceedings Vol. 6632:
Therapeutic Laser Applications and Laser-Tissue Interactions III
Alfred Vogel, Editor(s)

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