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Proceedings Paper

Determination of the optical properties of anisotropic biological media using isotropic and anisotropic diffusion models
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Paper Abstract

The anisotropic light propagation in biological tissue is investigated in the steady-state and time domains. Monte Carlo simulations performed for tissue that has anisotropic optical properties show that the steady-state and time-resolved reflectance depends strongly on the measurement direction. We examined the determination of the optical properties using an isotropic diffusion model and found that in the time domain, in contrast to steady-state spatially-resolved reflectance measurements, the obtained absorption coefficient does not depend on the measurement direction and is close to the correct value. We performed measurements of the steady-state and time-resolved reflectance from porcine and bovine tendon which confirmed the theoretical findings. In addition, we compared the results obtained from Monte Carlo simulations with the solutions of the anisotropic diffusion theory for reflectance from semi-infinite media and for transmittance from slabs. In contrast to the literature, we found that the anisotropic diffusion equation is, in general, not a valid approximation to the anisotropic light propagation even in the diffusive regime.

Paper Details

Date Published: 12 July 2007
PDF: 8 pages
Proc. SPIE 6629, Diffuse Optical Imaging of Tissue, 66290M (12 July 2007); doi: 10.1117/12.728323
Show Author Affiliations
Alwin Kienle, Institut für Lasertechnologien in der Medizin und Meβtechnik (Germany)
Corinna Wetzel, Institut für Lasertechnologien in der Medizin und Meβtechnik (Germany)
Andrea Bassi, Politecnico di Milano, ULTRAS-CNR-INFM and IFN-CNR (Italy)
Daniela Comelli, Politecnico di Milano, ULTRAS-CNR-INFM and IFN-CNR (Italy)
Paola Taroni, Politecnico di Milano, ULTRAS-CNR-INFM and IFN-CNR (Italy)
Antonio Pifferi, Politecnico di Milano, ULTRAS-CNR-INFM and IFN-CNR (Italy)


Published in SPIE Proceedings Vol. 6629:
Diffuse Optical Imaging of Tissue
Brian W. Pogue; Rinaldo Cubeddu, Editor(s)

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