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Proceedings Paper

Diagnostic potential of optical coherence tomography in non-melanoma skin cancer: a clinical study
Author(s): Mette Mogensen M.D.; Lars Thrane; Thomas M. Jørgensen; Gregor B. E. Jemec
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Paper Abstract

Introduction: Non-melanoma skin cancer (NMSC) is the most prevalent cancer in the Western World. OCT has proved potential in assisting clinical diagnosis and perhaps reducing the need for biopsies in NMSC. As non-invasive treatment is increasingly used for NMSC patients with superficial lesions, the development of non-invasive diagnostic technologies is highly relevant. Methods: The aim of this cross-sectional clinical study, enrolling 100 NMSC patients and 20 healthy volunteers, is to investigate the diagnostic accuracy and applicability of OCT in NMSC diagnosis. Our OCT-system has been developed at Risoe National Laboratory, Denmark and offers ppolarization sensitive-OCT (PS-OCT) that may have additional advantaged as NMSC differ in content of birefringent collagens from normal skin. Results: Basal cell carcinomas (BCC) can in some cases be distinguished from normal skin in OCT-images, as normal skin exhibits a layered structure this layering is not present in BCC and sometimes not in actinic keratosis (AK). BCC lesions seem to be clearly less reflective than normal tissue. The predictive value of OCT in NMSC will be presented from a clinical point of view. Discussion: The earlier a skin cancer is diagnosed, the better the prognosis. Estimation of diagnostic accuracy and abilities of OCT in clinical studies of skin cancer patients is essential to establish the role and future set-ups for diagnostic OCT-systems.

Paper Details

Date Published: 11 July 2007
PDF: 8 pages
Proc. SPIE 6627, Optical Coherence Tomography and Coherence Techniques III, 662708 (11 July 2007); doi: 10.1117/12.728273
Show Author Affiliations
Mette Mogensen M.D., Univ. of Copenhagen (Denmark)
Lars Thrane, Risø National Lab., Technical Univ. of Denmark (Denmark)
Thomas M. Jørgensen, Technical Univ. of Denmark (Denmark)
Gregor B. E. Jemec, Roskilde Hospital, Univ. of Copenhagen (Denmark)

Published in SPIE Proceedings Vol. 6627:
Optical Coherence Tomography and Coherence Techniques III
Peter E. Andersen; Zhongping Chen, Editor(s)

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