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Proceedings Paper

Path-length correction for the haemoglobin-concentration measurement using the skull cranial window by multi-spectral imaging analysis
Author(s): Koichiro Sakaguchi; Shunsuke Furukawa; Takushige Katsura; Kyoko Yamazaki; Hideo Kawaguchi; Atsushi Maki; Eiji Okada
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Paper Abstract

The concentration changes in oxygenated haemoglobin and deoxygenated haemoglobin in the brain cortex of guinea pigs associated with brain activation are measured from the multi-spectral images of the cortical tissue. The cortical tissue is observed through a thinned skull. The wavelength dependence of the optical path length is considered in the calculation of haemoglobin concentration. The results are compared with those obtained from the multi-spectral images of the exposed cortex to evaluate the influence of the thinned skull on the measurement of the concentration changes by multispectral imaging system. Although the skull thickness affected the sensitivity of the change in reflectance due to decrease in optical path in the cortical tissue, the influence of skull on the wavelength dependence of the optical path length can be ignored when the skull thickness is approximately less than 100 &mgr;m.

Paper Details

Date Published: 12 July 2007
PDF: 8 pages
Proc. SPIE 6629, Diffuse Optical Imaging of Tissue, 66290K (12 July 2007); doi: 10.1117/12.728225
Show Author Affiliations
Koichiro Sakaguchi, Keio Univ. (Japan)
Shunsuke Furukawa, Keio Univ. (Japan)
Takushige Katsura, Hitachi, Ltd. (Japan)
Kyoko Yamazaki, Hitachi, Ltd. (Japan)
Hideo Kawaguchi, Hitachi, Ltd. (Japan)
Atsushi Maki, Hitachi, Ltd. (Japan)
Eiji Okada, Keio Univ. (Japan)

Published in SPIE Proceedings Vol. 6629:
Diffuse Optical Imaging of Tissue
Brian W. Pogue; Rinaldo Cubeddu, Editor(s)

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