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Proceedings Paper

First clinical trials of the Twente photoacoustic mammoscope (PAM)
Author(s): Susanne E. Vaartjes; Johan C. G. van Hespen; Joost M. Klaase; Frank M. van den Engh; Andy K. H. Thé; Wiendelt Steenbergen; Ton G. van Leeuwen; Srirang Manohar
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Paper Abstract

Breast cancer dominates cancers in females. This burden on society and the room for improvements in the current practice of mammography have been stimuli for developing new modalities like photoacoustic mammography. At the University of Twente (UT), an instrument had been developed aimed at performing limited area scans on the human breast. This instrument is called the Twente Photoacoustic Mammoscope (PAM). The PAM is based on generating laserinduced ultrasound from absorbing structures in the breast. The heart of the instrument is a flat PVDF based detector matrix comprising 590 active elements. We show the performance characteristics of the ultrasound detector. The exciting source is an Nd:YAG laser operating at 1064 nm with 5 ns pulses. A study protocol was designed to explore the feasibility of using the PAM to detect cancer in the breasts of patients. The protocol was executed at the Medisch Spectrum Twente by using the mammoscope to obtain photoacoustic region-of-interest (ROI) images of the suspect/symptomatic breasts. We compare the photoacoustic images obtained with x-ray mammograms and ultrasound images. We show photoacoustic images of ROI in one case where we attribute high intensity regions to tumor vascularization.

Paper Details

Date Published: 12 July 2007
PDF: 12 pages
Proc. SPIE 6629, Diffuse Optical Imaging of Tissue, 662917 (12 July 2007); doi: 10.1117/12.728044
Show Author Affiliations
Susanne E. Vaartjes, Univ. of Twente (Netherlands)
Johan C. G. van Hespen, Univ. of Twente (Netherlands)
Joost M. Klaase, Medisch Spectrum Twente (Netherlands)
Frank M. van den Engh, Medisch Spectrum Twente (Netherlands)
Andy K. H. Thé, Medisch Spectrum Twente (Netherlands)
Wiendelt Steenbergen, Univ. of Twente (Netherlands)
Ton G. van Leeuwen, Univ. of Twente (Netherlands)
Srirang Manohar, Univ. of Twente (Netherlands)


Published in SPIE Proceedings Vol. 6629:
Diffuse Optical Imaging of Tissue
Brian W. Pogue; Rinaldo Cubeddu, Editor(s)

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