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Proceedings Paper

Time-resolved diffuse reflectance at small source-detector separation using a time-gated single-photon avalanche diode
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Paper Abstract

We demonstrate the feasibility of time-resolved diffuse reflectance at small source-detector separations using a single-photon avalanche diode (SPAD) operated in time-gated mode. Photon time distributions at an interfiber distance of 0.2 cm were obtained on tissue phantoms with a reduced scattering coefficient of 10 cm-1, and an absorption coefficient of 0.1 cm-1, with a dynamic range of 106 and collecting photons at arrival times up to 4 ns. By time-gating the initial photons, carrying information mainly from superficial layers, it is possible to detect longer lived photons that have explored deeper depths even at almost null interfiber distances. The proposed approach should provide higher number of photons at any arrival time, higher contrast, and better spatial resolution as compared to longer interfiber distances.

Paper Details

Date Published: 17 July 2007
PDF: 5 pages
Proc. SPIE 6631, Novel Optical Instrumentation for Biomedical Applications III, 66310B (17 July 2007); doi: 10.1117/12.727947
Show Author Affiliations
Antonio Pifferi, IIT, ULTRAS-INFM-CNR and IFN-CNR, Politecnico di Milano (Italy)
Alessandro Torricelli, IIT, ULTRAS-INFM-CNR and IFN-CNR, Politecnico di Milano (Italy)
Lorenzo Spinelli, IIT, ULTRAS-INFM-CNR and IFN-CNR, Politecnico di Milano (Italy)
Davide Contini, IIT, ULTRAS-INFM-CNR and IFN-CNR, Politecnico di Milano (Italy)
Rinaldo Cubeddu, IIT, ULTRAS-INFM-CNR and IFN-CNR, Politecnico di Milano (Italy)
Fabrizio Martelli, Univ. degli Studi di Firenze (Italy)
Giovanni Zaccanti, Univ. degli Studi di Firenze (Italy)
Alberto Tosi, Politecnico di Milano (Italy)
Alberto Dalla Mora, Politecnico di Milano (Italy)
Franco Zappa, Politecnico di Milano (Italy)
Sergio Cova, Politecnico di Milano (Italy)


Published in SPIE Proceedings Vol. 6631:
Novel Optical Instrumentation for Biomedical Applications III
Christian D. Depeursinge, Editor(s)

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