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Proceedings Paper

Combination of panoramic and fluorescence endoscopic images to obtain tumor spatial distribution information useful for bladder cancer detection
Author(s): S. Olijnyk; Y. Hernández Mier; W. C. P. M. Blondel; C. Daul; D. Wolf; G. Bourg-Heckly
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Paper Abstract

Bladder cancer is widely spread. Moreover, carcinoma in situ can be difficult to diagnose as it may be difficult to see, and become invasive in 50 % of case. Non invasive diagnosis methods like photodynamic or autofluorescence endoscopy allow enhancing sensitivity and specificity. Besides, bladder tumors can be multifocal. Multifocality increases the probability of recurrence and infiltration into bladder muscle. Analysis of spatial distribution of tumors could be used to improve diagnosis. We explore the feasibility to combine fluorescence and spatial information on phantoms. We developed a system allowing the acquisition of consecutive images under white light or UV excitation alternatively and automatically along the video sequence. We also developed an automatic image processing algorithm to build a partial panoramic image from a cystoscopic sequence of images. Fluorescence information is extracted from wavelength bandpass filtered images and superimposed over the cartography. Then, spatial distribution measures of fluorescent spots can be computed. This cartography can be positioned on a 3D generic shape of bladder by selecting some reference points. Our first results on phantoms show that it is possible to obtain cartography with fluorescent spots and extract quantitative information of their spatial distribution on a "wide" field of view basis.

Paper Details

Date Published: 18 July 2007
PDF: 9 pages
Proc. SPIE 6631, Novel Optical Instrumentation for Biomedical Applications III, 66310X (18 July 2007); doi: 10.1117/12.727878
Show Author Affiliations
S. Olijnyk, CNRS-INPL-UHP, Nancy Univ. (France)
Y. Hernández Mier, CNRS-INPL-UHP, Nancy Univ. (France)
W. C. P. M. Blondel, CNRS-INPL-UHP, Nancy Univ. (France)
C. Daul, CNRS-INPL-UHP, Nancy Univ. (France)
D. Wolf, CNRS-INPL-UHP, Nancy Univ. (France)
G. Bourg-Heckly, CNRS, UMR 7033, Univ. Paris VI (France)

Published in SPIE Proceedings Vol. 6631:
Novel Optical Instrumentation for Biomedical Applications III
Christian D. Depeursinge, Editor(s)

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