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Proceedings Paper

Dynamic imaging of penetration and decontamination after chemical eye burn using optical coherence tomography
Author(s): Felix Spöler; Michael Först; Heinrich Kurz; Markus Frentz; Norbert F. Schrage
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Paper Abstract

For chemical burns a considerable lack of methods exists for defining penetration kinetics and effects of decontamination within biological structures. We demonstrate that time-resolved high-resolution optical coherence tomography can close this gap by monitoring changes in scattering properties and thicknesses of rabbit cornea ex vivo after topical application of different corrosives. Modifications in the corneal microstructure due to direct chemical interaction or changes in the hydration state as a result of osmotic imbalance compromise the corneal transparency. The associated increase in light scattering intensity within the cornea is observed with high spatial and temporal resolution. Parameters affecting the severity of pathophysiological damage like diffusion velocity, depth of penetration, resistance of barriers, and effectiveness of emergency treatment procedures are obtained. This study demonstrates the potential of high-resolution OCT for the visualization and direct non-invasive measurement of specific interaction of chemicals with the eye, exemplified on hydrofluoric acid burn.

Paper Details

Date Published: 11 July 2007
PDF: 7 pages
Proc. SPIE 6627, Optical Coherence Tomography and Coherence Techniques III, 66270B (11 July 2007); doi: 10.1117/12.727820
Show Author Affiliations
Felix Spöler, RWTH Aachen Univ. (Germany)
Michael Först, RWTH Aachen Univ. (Germany)
Heinrich Kurz, RWTH Aachen Univ. (Germany)
Markus Frentz, Aachen Ctr. of Technology Transfer in Ophthalmology (Germany)
Norbert F. Schrage, Aachen Ctr. of Technology Transfer in Ophthalmology (Germany)

Published in SPIE Proceedings Vol. 6627:
Optical Coherence Tomography and Coherence Techniques III
Peter E. Andersen; Zhongping Chen, Editor(s)

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