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Proceedings Paper

Time-resolved diffuse optical spectroscopy of small tissue samples
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Paper Abstract

Time-resolved transmittance measurements were performed in the wavelength range of 610 or 700 to 1050 nm on phantom slabs and bone tissue cubes of different sizes. The data were best fitted with solutions of the diffusion equation for an infinite slab and for a parallelepiped to investigate how size and optical properties of the samples affect the results obtained with the two models. When small samples are considered, the slab model overestimates both optical coefficients, especially the absorption. The parallelepiped model largely compensates for the small sample size and performs much better also when the absorption spectra are interpreted with the Beer's law to estimate bone tissue composition.

Paper Details

Date Published: 19 July 2007
PDF: 5 pages
Proc. SPIE 6628, Diagnostic Optical Spectroscopy in Biomedicine IV, 66281A (19 July 2007); doi: 10.1117/12.727787
Show Author Affiliations
Paola Taroni, IIT, ULTRAS-CNR-INFM and IFN-CNR, Politecnico di Milano (Italy)
Daniela Comelli, IIT, ULTRAS-CNR-INFM and IFN-CNR, Politecnico di Milano (Italy)
Andrea Farina, IIT, ULTRAS-CNR-INFM and IFN-CNR, Politecnico di Milano (Italy)
Antonio Pifferi, IIT, ULTRAS-CNR-INFM and IFN-CNR, Politecnico di Milano (Italy)
Alwin Kienle, Institut für Lasertechnologien in der Medizin und Meßtechnik (Germany)


Published in SPIE Proceedings Vol. 6628:
Diagnostic Optical Spectroscopy in Biomedicine IV
Dietrich Schweitzer; Maryann Fitzmaurice, Editor(s)

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