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Proceedings Paper

Non-ergodicity correction in laser speckle biomedical imaging
Author(s): P. Zakharov; A. C. Völker; F. Buck; B. Weber; F. Scheffold
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Paper Abstract

We discuss a new approach to laser speckle biomedical imaging with the goal to establish a quantitative link between the measured signal and the local dynamic properties of Brownian motion or blood flow. We demonstrate that the presence of a static component in laser speckle imaging signal can significantly complicate the quantitative interpretation of the imaging data. With Monte-Carlo simulations and model experiments we show that the error in the mean particles velocity extracted using traditional approaches can reach several orders of magnitude. With a proper data treatment on the other side the error can be substantially reduced. We suggest a simple data processing scheme that properly accounts for a static component in the scattered light intensity.

Paper Details

Date Published: 18 July 2007
PDF: 9 pages
Proc. SPIE 6631, Novel Optical Instrumentation for Biomedical Applications III, 66310D (18 July 2007); doi: 10.1117/12.727646
Show Author Affiliations
P. Zakharov, Univ. of Fribourg (Switzerland)
Solianis Monitoring AG (Switzerland)
A. C. Völker, Univ. of Fribourg (Switzerland)
F. Buck, Univ. Hospital Zürich (Switzerland)
B. Weber, Univ. Hospital Zürich (Switzerland)
F. Scheffold, Univ. of Fribourg (Switzerland)


Published in SPIE Proceedings Vol. 6631:
Novel Optical Instrumentation for Biomedical Applications III
Christian D. Depeursinge, Editor(s)

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