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The influence of the protoporphyrin diamino acid derivatives photodynamic effect on the activity of selected enzymes
Author(s): Anna Romiszewska; Dariusz Pietrzykowski; Alfreda Graczyk
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Paper Abstract

Photodynamic Therapy (PDT) requires three components: a dye applied as the photosensitizer, a source of light, and a possibly large amount of oxygen dissolved in the tissue. The considerably higher absorption of porphyrin photosensitizers by tumorous tissues allows the application of these photosensitizers in the diagnosis and therapy of tumors. The cytotoxic and cytolethal effects of the photodynamic therapy are associated with the formation of a singlet oxygen or production of radical species by the porphyrin photosensitizers. In the cell, the singlet oxygen or radical species impair important macromolecules like membrane phospholipids, structural proteins, enzymes, and DNA. This study describes the photodynamic effect of the PP(AA)2Arg2 group photosensitizers on the activity of adenosine deaminase, DNA-ase and trypsin in relation to the photosensitizer dose and the excitation energy.

Paper Details

Date Published: 23 January 2007
PDF: 5 pages
Proc. SPIE 6598, Laser Technology VIII: Applications of Lasers, 659803 (23 January 2007); doi: 10.1117/12.726525
Show Author Affiliations
Anna Romiszewska, Military Univ. of Technology (Poland)
Dariusz Pietrzykowski, Jelfa SA (Poland)
Alfreda Graczyk, Military University of Technology, (Poland)

Published in SPIE Proceedings Vol. 6598:
Laser Technology VIII: Applications of Lasers

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