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Proceedings Paper

White noise and synchronization shaping the age structure of the human population
Author(s): Stanislaw Cebrat; Przemyslaw Biecek; Katarzyna Bonkowska; Mateusz Kula
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Paper Abstract

We have modified the standard diploid Penna model of ageing in such a way that instead of threshold of defective loci resulting in genetic death of individuals, the fluctuation of environment and "personal" fluctuations of individuals were introduced. The sum of the both fluctuations describes the health status of the individual. While environmental fluctuations are the same for all individuals in the population, the personal component of fluctuations is composed of fluctuations corresponding to each physiological function (gene, genetic locus). It is rather accepted hypothesis that physiological parameters of any organism fluctuate highly nonlinearly. Transition to the synchronized behaviors could be a very strong diagnostic signal of the life threatening disorder. Thus, in our model, mutations of genes change the chaotic fluctuations representing the function of a wild gene to the synchronized signals generated by mutated genes. Genes are switched on chronologically, like in the standard Penna model. Accumulation of defective genes predicted by Medawar's theory of ageing leads to the replacement of uncorrelated white noise corresponding to the healthy organism by the correlated signals of defective functions. As a result we have got the age distribution of population corresponding to the human demographic data.

Paper Details

Date Published: 15 June 2007
PDF: 9 pages
Proc. SPIE 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, 66020O (15 June 2007); doi: 10.1117/12.725551
Show Author Affiliations
Stanislaw Cebrat, Wrocław Univ. (Poland)
Przemyslaw Biecek, Wrocław Univ. (Poland)
Katarzyna Bonkowska, Wrocław Univ. (Poland)
Mateusz Kula, Wrocław Univ. (Poland)

Published in SPIE Proceedings Vol. 6602:
Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems
Sergey M. Bezrukov, Editor(s)

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