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Proceedings Paper

Mechanism of intracellular Ca2+ oscillations and interspike interval distributions
Author(s): M. Falcke
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Paper Abstract

The dynamics of cytosolic Ca2+ concentration exhibits oscillations with a wide range of periods. It was suggested in recent years by several modelling studies that these oscillations do not result from an oscillatory local dynamics but that fluctuations drive the formation of spatial and temporal structures in a non-oscillatory dynamic regime. Fluctuations arise from the random opening and closing of release channels on the membrane of the endoplasmic reticulum. Consequently, the interspike interval (ISI) has not a sharp value as with regular oscillations but distributions of ISI arise. We present these distributions and relate them to underlying processes. Oscillations with long average ISI can be comprehended as repetitive wave triggering. The standard deviation of the ISI approximates the inverse of the triggering rate. Oscillations with short average ISI are often complex oscillations consisting of base line oscillations and intermittent oscillations on an elevated cytosolic Ca2+ level.

Paper Details

Date Published: 8 June 2007
PDF: 12 pages
Proc. SPIE 6602, Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems, 66020M (8 June 2007); doi: 10.1117/12.725116
Show Author Affiliations
M. Falcke, Hahn Meitner Institut (Germany)

Published in SPIE Proceedings Vol. 6602:
Noise and Fluctuations in Biological, Biophysical, and Biomedical Systems
Sergey M. Bezrukov, Editor(s)

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